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Rh(D) (rhesus) negative blood & pregnancy

blood groupsEveryone belongs to one of four blood groups: A, B, AB or O. These groups are defined by the types of protein on your red blood cells.

But your blood type is also classified by another protein called Rh(D) (formerly known as the rhesus factor). Most people have this protein on their red blood cells and are called Rh(D) positive. If you do not have this protein, you're Rh(D) negative.

Being Rh(D) negative isn't a bad thing – it doesn't usually cause any health problems.

But if you're pregnant, there are some things you need to know about.

Being Rh(D) negative during pregnancy

You and your pēpi (baby) have separate blood supplies. Usually, only nutrients and waste products move across the placenta between you and your pēpi, while blood doesn't. But problems can occasionally happen if you have Rh(D) negative blood and your pēpi has Rh(D) positive blood, and some of your baby's red blood cells cross the placenta to come into contact with your blood.

If this happens, your immune system can make antibodies, which attack and destroy your baby's red blood cells because they're different. As a result, your pēpi gets anaemia (meaning they have low numbers of red blood cells). They then release a substance called bilirubin, which causes jaundice. This doesn't happen if you're Rh(D) positive and your pēpi is Rh(D) negative.

We can stop this happening by giving you a medication called anti-D within 72 hours (three days) of your baby's blood crossing the placenta. But if you start making antibodies, nothing can stop it and it will continue happening in the future. This may affect future pregnancies.

Sensitising events

There are several situations in which your baby's blood could cross the placenta:

These are called sensitising events because there is a risk your baby's blood has crossed the placenta and your body has started making antibodies. If any of these things happen, contact your midwife. You need to have anti-D within 72 hours to stop your body making antibodies.

Preventing this from happening

If you have a sensitising event, your midwife or doctor will offer you an injection of anti-D. Anti-D is a blood product made from donated blood. It helps to remove your baby's red blood cells from your body, so you stop making antibodies against them. This prevents harm to your pēpi baby and any pēpi you have in the future and has a 90% chance of working.

After your pēpi is born, blood from the umbilical cord or placenta will be tested to check your baby's blood group. If they have Rh(D) positive blood, your midwife will offer to give you an injection of anti-D. If they have Rh(D) negative blood, you will not need to have anti-D because there is no risk of making antibodies.

Side effects of anti-D

In very rare cases, anti-D may cause a severe allergic reaction. For this reason, it's best to have it at a hospital or GP surgery.

Beyond that, anti-D is very safe. You may get soreness at the injection site, and there is a small chance you may get a fever, headache or rash after the injection.

As with any blood product in New Zealand, anti-D is checked for infections before you receive it to keep you as safe as possible.

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Written by HealthInfo clinical advisers. Last reviewed December 2021.


Page reference: 58327

Review key: HIPRC-41255