Print this topic

HealthInfo Canterbury


MGUS stands for monoclonal gammopathy of unknown significance. It's a benign (non-cancerous) condition where the body makes an abnormal protein, called a paraprotein. This abnormal protein is found in your blood or urine.

We don't know what causes MGUS. It's more common as we get older.

MGUS doesn't cause any symptoms so it's only picked up from blood or urine tests taken for another reason.

MGUS usually doesn't need any treatment. In most people, it remains stable and never causes any problems. However, if you have this it's important to have ongoing checkups, as occasionally MGUS can develop into a cancer such as myeloma or lymphoma. Your GP will usually follow up with blood and urine tests every six to 12 months.

See your GP if you have any of these symptoms:

  HealthInfo recommends the following pages

Written by HealthInfo clinical advisers. Endorsed by clinical director, Haematology Department, Canterbury DHB. Last reviewed May 2020.

Page reference: 62267

Review key: HIMGU-16173